BackgroundAn increasing number of studies utilize intracranial electrophysiology in human subjects to advance basic neuroscience knowledge. However, the use of neurosurgical patients as human research subjects raises important ethical considerations, particularly regarding informed consent and undue influence, as well as subjects’ motivations for participation. Yet a thorough empirical examination of these issues in a participant population has been lacking. The present study therefore aimed to empirically investigate ethical concerns regarding informed consent and voluntariness in Parkinson’s disease patients undergoing deep brain (...) stimulator (DBS) placement who participated in an intraoperative neuroscience study.MethodsTwo semi-structured 30-minute interviews were conducted preoperatively and postoperatively via telephone. Interviews assessed participants’ motivations for participation in the parent intraoperative study, recall of information presented during the informed consent process, and participants’ postoperative reflections on the research study.ResultsTwenty-two participants (mean age = 60.9) completed preoperative interviews at a mean of 7.8 days following informed consent and a mean of 5.2 days prior to DBS surgery. Twenty participants completed postoperative interviews at a mean of 5 weeks following surgery. All participants cited altruism or advancing medical science as “very important” or “important” in their decision to participate in the study. Only 22.7% (n = 5) correctly recalled one of the two risks of the study. Correct recall of other aspects of the informed consent was poor (36.4% for study purpose; 50.0% for study protocol; 36.4% for study benefits). All correctly understood that the study would not confer a direct therapeutic benefit to them.ConclusionEven though research coordinators were properly trained and the informed consent was administered according to protocol, participants demonstrated poor retention of study information. While intraoperative studies that aim to advance neuroscience knowledge represent a unique opportunity to gain fundamental scientific knowledge, improved standards for the informed consent process can help facilitate their ethical implementation. (shrink)

This paper examines the business practices of socially responsible entrepreneurs with particular focus on activities that directly impact their companies’ finances. We collect case studies of 30 recognized socially responsible entrepreneurial firms from a wide range of industries. We analyze how and to what extent the entrepreneurs and their companies balance their profit objectives with their social or environmental goals. Our results indicate that the companies pursue profits in manners comparable to those of most conventional businesses. However, we learn that (...) our companies make certain deliberate exceptionsin their business practices to exercise their beliefs, although such actions may reduce profi ts. We also observe the entrepreneurs making efforts to identify situations that simultaneously increase the companies’ profits and serve their causes. Most companies choose to stay private and commit to building an enduring organization rather than pursue the conventional exit strategies. Finally, we find that many of the companies in our list commit themselves to and proactively manage formalized giving programs. (shrink)

Proceedings of a forum held in Austin, Tex., on Mother's Day, 1996.

Background Protecting a person’s right to privacy and confidentiality is important in healthcare services. As future health professionals, nursing students should bear the same responsibility as qualified health professionals in protecting patient privacy. Objectives To investigate nursing students’ practices of patient privacy protection and to identify factors associated with their practices. Research design A cross-sectional study design was adopted. A two-part survey was used to collect two types of data on nursing students: (1) personal characteristics, including demographics, clinical experience and (...) use of information and communication technology and social media and (2) practice of patient privacy protection, collected using the Patient Privacy Scale. Participants and research context: A total of 319 nursing students aged 18 or above, studying pre-registration nursing programmes and who had attended at least one block of clinical placement, were recruited from a university in Hong Kong. Ethical considerations The study received ethical approval from the Survey and Behavioural Research Ethics Committee of the Chinese University of Hong Kong. The participants were informed of the study aim and written consent was obtained before completing the survey. Findings: The mean total score on the Patient Privacy Scale was 119.7 out of 135. Nursing students who were regular users of Instagram and those who had never taken photographs with patients and hence did not need to obtain patient consent were associated with better practices of patient privacy protection (higher total scores on the Patient Privacy Scale). Conclusions The findings improve our understanding of nursing students’ practice of patient privacy protection and the associated factors. This will inform the development and revision of current strategies to enhance nursing students’ practice of patient privacy protection, especially their use of social media. (shrink)

This study explored the influence of the COVID-19 pandemic on perceived health behaviors; physical activity, sleep, and diet behaviors, alongside associations with wellbeing. Participants were 1,140 individuals residing in the United Kingdom, South Korea, Finland, Philippines, Latin America, Spain, North America, and Italy. They completed an online survey reporting possible changes in the targeted behaviors as well as perceived changes in their physical and mental health. Multivariate analyses of covariance on the final sample revealed significant mean differences regarding perceived physical (...) and mental health “over the last week,” as well as changes in health behaviors during the pandemic by levels of physical activity and country of residence. Follow up analyses indicated that individuals with highest decrease in physical activity reported significantly lower physical and mental health, while those with highest increase in physical activity reported significantly higher increase in sleep and lower weight gain. United Kingdom participants reported lowest levels of physical health and highest increase in weight while Latin American participants reported being most affected by emotional problems. Finnish participants reported significantly higher ratings for physical health. The physical activity by country interaction was significant for wellbeing. MANCOVA also revealed significant differences across physical activity levels and four established age categories. Participants in the oldest category reported being significantly least affected by personal and emotional problems; youngest participants reported significantly more sleep. The age by physical activity interaction was significant for eating. Discussed in light of Hobfoll conservation of resources theory, findings endorse the policy of advocating physical activity as a means of generating and maintaining resources combative of stress and protective of health. (shrink)

As a result of the COVID-19 pandemic people have endured potentially stressful challenges which have influenced behaviors such as eating. This pilot study examined the effectiveness of two brief interventions aimed to help individuals deal with food cravings and associated emotional experiences. Participants were 165 individuals residing in United Kingdom, Finland, Philippines, Spain, Italy, Brazil, North America, South Korea, and China. The study was implemented remotely, thus without any contact with researchers, and involved two groups. Group one participants were requested (...) to use daily diaries for seven consecutive days to assess the frequency of experience of their food cravings, frequency of giving in to cravings, and difficulty resisting cravings, as well as emotional states associated with their cravings. In addition to completing daily food diaries, participants in group two were asked to engage in mindful eating practice and forming implementation intentions. Participants assessed their perceived changes in eating, wellbeing, and health at the beginning and end of the intervention. Repeated measures MANOVAs indicated that participants experienced significantly less food cravings, as well as lower intensities of unpleasant states associated with cravings across time. In contrast to our hypothesis, the main effects of the group were not significant. Participants reported less eating and enhanced wellbeing at the end of the study. Our findings can be used to inform future remote interventions to manage food cravings and associated emotions and highlight the need for alternative solutions to increase participant engagement. (shrink)

Despite the importance of the co-evolution approach in various branches of research, such as strategy, organisation theory, complexity, population ecology, technology and innovation (Lewin et al., 1999; March, 1991), co-evolution has been relatively neglected in international business and ethics research (Madhok and Phene, 2001). The purpose of this article is to show how co-evolution theory provides a theoretical framework within which some issues of ethics research are addressed. Our analysis is in the context of the contrasts between business systems (North, (...) 1990), and in particular the distinction between informal systems and those systems where institutions are formalised in law. This complements the growing research on comparative corporate governance and capitalisms (Chandler and Hikino, 1990; Choi et al., 1999; Whitley, 1994). The synthesis of co-evolution and analysis of divergent institutional environments in ethics research can also complement the globalisation and MNE approaches to international business research. (shrink)

Background: Pulsed dye laser is the gold standard for treatment of port-wine stain birthmarks but multiple treatments are required and complete resolution is often not achieved. Posttreatment vessel recurrence is thought to be a factor that limits efficacy of PDL treatment of PWS. Imiquimod 5% cream is an immunomodulator with antiangiogenic effects. Objective: We sought to determine if application of imiquimod 5% cream after PDL improves treatment outcome. Methods: Healthy individuals with PWS were treated with PDL and then randomized to (...) apply posttreatment placebo or imiquimod 5% cream for 8 weeks. Chromameter measurements for 57 PWS sites were taken at baseline and compared with measurements taken 8 weeks posttreatment. The Δa and ΔE were measured to quantify treatment outcome. Results: Two patients developed minor skin irritation. Other adverse effects were not noted. Average a was 0.43 for PDL + placebo sites and 1.27 for PDL + imiquimod sites indicating a greater reduction in erythema with imiquimod. Average E was 2.59 for PDL + placebo and 4.08 for PDL + imiquimod, again indicating a greater color improvement with imiquimod. Limitations: Effects were evaluated after a single treatment and duration of effect is unknown. Conclusion: Combined selective photothermolysis and antiangiogenic therapy may enhance PWS treatment efficacy. © 2011 by the American Academy of Dermatology, Inc. (shrink)

Professional, Ethical, Legal, and Educational Lessons in Medicine: A Problem Based Approach provides a comprehensive review of the complex and challenging field of professional medical practice. Its problem-based format incorporates a vast pool of practical, board-exam-style multiple-choice questions for self-assessment, and is an ideal resource for exam preparation as well as ongoing clinical education among trainees and clinicians The practice of medicine is not only about clinical care of patients. Physicians must navigate ethical conundrums, legal pitfalls, and quality improvement issues (...) while maintaining scrupulous professionalism and being exemplary educators. This volume addresses common issues in the realm of professional medical practice not typically covered in other texts. Each of the 73 chapters presents a problem-based case that branches out into an oral board examination type stem questions. A discussion section with brief review articles summarizes the most recent literature. Multiple-choice questions with answers allows for comprehensive self-assessment or interactive group quizzes. This book will appeal to medical and allied health professionals in all specialties of medicine. It is an excellent and hands-on reference for the related but diverse domains associated with professional healthcare practice by students, physicians, and other healthcare providers compacted into one volume. (shrink)

Altruism is a well-established reason underlying research participation. Less is known about altruism in adolescent-parent decision-making about clinical trials enrolling healthy adolescents. This qualitative investigation focused on identifying spontaneous statements of altruism within adolescent-parent discussions of participation in a hypothetical phase I clinical trial related to adolescent sexual health. Content analysis revealed several response patterns to each other’s altruistic reasoning. Across 70 adolescent-parent dyads in which adolescents were 14 to 17 years of age and 91% of their parents were mothers, (...) a majority of dyadic discussions included a statement reflecting altruism. Parents responded to adolescents’ statements of altruism more frequently than adolescents responded to parents’ statements. Responses included: expresses concern, reiterates altruistic reasoning, agrees with altruistic reasoning, and adds to/expands altruistic reasoning. Since an altruistic perspective was often balanced with concerns about risk or study procedures, researchers cannot assume that altruism will directly lead to study participation. Optimizing the informed consent process for early phase clinical trials involving healthy adolescents may include supporting parents to have conversations with their adolescents which will enhance their capacity to consider all aspects of trial participation. (shrink)

The arguments offered by Jaswal & Akhtar to counter the social motivation theory do not appear to be directly related to the SMT tenets and predictions, seem to not be empirically testable, and are inconsistent with empirical evidence. To evaluate the merits and shortcomings of the SMT and identify scientifically testable alternatives, advances are needed on the conceptualization and operationalization of social motivation across diagnostic boundaries.

James Allen, qui fut pendant 21 ans le mari d’Abigail, mourut à la suite d’un accident du travail. C’est à cette époque que les médecins découvrirent qu’Allen était une femme. De nombreux journaux britanniques en parlèrent. Cet article situe le cas d’Allen dans le contexte plus large des female husbands (telles que Mary Hamilton et Catherine Vizzani) et analyse trois aspects récurrents dans la presse de 1829, ainsi que dans les autres récits : d’abord le travestissement et la dissimulation, ensuite (...) la sexualité féminine, y compris le lesbianisme, et enfin la terminologie utilisée, ce qui ouvre un débat sur la multiplicité générique, confrontée à l’organisation dichotomique de la société. (shrink)

The process of robotization and the introduction of artificial intelligence which are linked to the 4.0 Industrial Revolution imply economic and social changes. This article analyzes its implications for the Spanish labor market, discussing the existence of possible imbalances, present or future, between the supply and demand of workers. For this reason this study assesses, on the one hand, the recent evolution of the Spanish productive structure and, on the other, the labor supply. More specifically, special attention is paid to (...) the educational level and skills of the workers, since they are central in the definition of the professional profiles generated as a result of the digitization and automation of the economy. A number of the strengths and weaknesses of the formative structure of the Spanish population are then discussed. The 4.0 Industrial Revolution creates new opportunities for workers with a higher level of training and high digital, financial or STEM skills. On the contrary, older workers and workers with a lower level of training appear among the most vulnerable groups. The introduction of reforms in the training system is urgent not only to consolidate the process of economic transformation, but also to minimize the social costs associated with the 4.0 Industrial Revolution. (shrink)

[M]y attention was drawn to the flower garden of the grey matter, which contained cells with delicate and elegant forms, the mysterious butterflies of the soul, the beating of whose wings may someday... clarify the secret of mental life. Art can actually facilitate scientific understanding, even discovery. Art can be, and has been, the entryway to vision and the understanding of natural phenomena as demonstrated in its role in the development of neuron theory. While developing a course on current brain (...) research and learning and then projects for S.T.E.A.M. curriculum, I was repeatedly drawn to the work of Santiago Ramon y Cajal, whose life work provides an extraordinary example of the.. (shrink)

This paper discusses Baker’s Enhanced Indispensability Argument for mathematical realism on the basis of the indispensable role mathematics plays in scientific explanations of physical facts, along with various responses to it. I argue that there is an analogue of causal explanation for mathematics which, of several basic types of explanation, holds the most promise for use in the EIA. I consider a plausible case where mathematics plays an explanatory role in this sense, but argue that such use still does not (...) support realism about mathematical objects. (shrink)

James Allen, qui fut pendant 21 ans le mari d’Abigail, mourut à la suite d’un accident du travail. C’est à cette époque que les médecins découvrirent qu’Allen était une femme. De nombreux journaux britanniques en parlèrent. Cet article situe le cas d’Allen dans le contexte plus large des female husbands (telles que Mary Hamilton et Catherine Vizzani) et analyse trois aspects récurrents dans la presse de 1829, ainsi que dans les autres récits : d’abord le travestissement et la dissimulation, ensuite (...) la sexualité féminine, y compris le lesbianisme, et enfin la terminologie utilisée, ce qui ouvre un débat sur la multiplicité générique, confrontée à l’organisation dichotomique de la société. (shrink)

Peirce’s response to the anti-metaphysical positivism of his day draws on Kant’s response to Hume, but moves beyond it, being thus a valuable resource, especially in our own post-Logical Positivist era. Kant’s legacy to Peirce was a lasting conviction that metaphysics need not be the hopelessly "airy science" Hume had pooh-poohed, but could and should become a legitimate and valuable area of investigation. Peirce's legacy to philosophy today is a distinctively plausible post-Kantian reconstruction of how this might be achieved.

A natural language is an organic living thing; and meanings change as words take on new, and shed old, connotations. Recent philosophy of language has paid little attention to the growth of meaning; radical philosophers like Feyerabend and Rorty have suggested that meaning-change undermines the pretensions of science to be a rational enterprise. Thinkers in the classical pragmatist tradition, however -Peirce in philosophy of science and, more implicitly, Holmes in legal theory- both recognized the significance of growth of meaning, and (...) understood how it can contribute to the progress of science and to the adaptation of a legal system to changing circumstances. This paper develops these insights, and illustrates them by reference to the growth of meaning of "DNA" from the identification of "nuclein" to the discovery of mtDNA almost a century later, and the growth of meaning of "the establishment of religion" in the First Amendment to the U.S. Constitution from its ratification in 1791 to the present day. Arguing that the growth of meaning can indeed contribute to rationality, it also shows why narrowly formal models are inadequate both to science and to law. Un lenguaje natural es una cosa viviente orgánica, y los significados cambian a medida que las palabras adoptan nuevas connotaciones y abandonan viejas. La filosofía del lenguaje reciente ha prestado poca atención al desarrollo del significado; filósofos radicales, como Feyerabend y Rorty han sugerido que el cambio de significado socava las pretensiones de la ciencia de ser una empresa racional. Pensadores en la tradición pragmatista clásica, sin embargo -Peirce en la filosofía de la ciencia y, más implícitamente, Holmes en la teoría del Derecho- reconocieron la importancia del desarrollo del significado y comprendieron cómo éste puede contribuir al progreso de la ciencia y a la adaptabilidad de un sistema jurídico a las circunstancias cambiantes. Este trabajo desarrolla estas ideas, y las ilustra por medio de una referencia a el desarrollo del significado de "ADN" desde la identificación de la "nucleína" hasta el descubrimiento del ADN mitocondrial casi un siglo más tarde, y el desarrollo del significado de "el establecimiento de una religión" en la Primera Enmienda de la Constitución de los Estados Unidos desde su ratificación en 1791 hasta la actualidad. Argumentando que el desarrollo del significado puede contribuir mucho a la racionalidad, también muestra por qué los modelos estrechamente formales son inadecuados, tanto para la ciencia como para el Derecho. (shrink)

Los materiales producidos por entidades ligadas a la salud de las infancias como la OMS, UNICEF o la OPS tienden a enumerar argumentos en contra de las tecnologías, desde los que se desalienta el “uso”, la “exposición” o el “consumo” de pantallas por parte de niñas y niños. Los diseños curriculares para la educación inicial, al contrario, se refieren a las tecnologías como parte de los saberes a enseñar, como oportunidades para la innovación, potenciales recursos para la enseñanza o incluso (...) como rasgos de las llamadas nuevas infancias. En este artículo procuraremos analizar los escenarios de encuentro entre infancias y tecnologías que surgen de ambas fuentes, sobre la hipótesis de que consideran escenarios muy diferentes: no hablan de las mismas tecnologías ni de las mismas infancias. La producción se inscribe en un estudio en curso de la Universidad Pedagógica Nacional, titulado “Infancias, tecnologías digitales y escuela: un análisis desde la educación infantil”. (shrink)

RESUMENSe analiza la integridad de la ciencia, entendida como la firme adhesión a valores epistemoló- gicos. Los valores fundamentales considerados son el respeto por las pruebas y el intercambio de pruebas. Paralelamente se examinan las amenazas actuales a estos valores, en particular en el campo de la investigación biomédica y farmacéutica.PALABRAS CLAVEINVESTIGACIÓN BIOMÉDICA, VALORES EPISTEMOLÓGICOS, INTERCAMBIO DE PRUEBAS, RESPETO POR LAS PRUEBASABSTRACTThe integrity of science understood as the firm adherence to epistemological values is analysed in this paper. Respect for evidence (...) and evidence-sharing are considered to be core values. At the same time, the author examines the current threats to these values, especially in the fields of biomedical and pharmaceutical research.KEYWORDSBIOMEDICAL RESEARCH, EPISTEMOLOGICAL VALUES, EVIDENCE-SHARING, RESPECT FOR EVIDENCE. (shrink)

Este ensayo propone una hipótesis: que el modelo de Sujeto “educable” y “moral” que expone José Enrique Rodó en su Ariel puede corresponderse con el ideal de mousikós (??st?ó?), término griego que, según ciertas acepciones, se traduce por “culto” o “cultivado”, y que designaba a las personas eruditas.

Para entender por qué la interacción de la ciencia y el derecho puede ser tan problemática, no basta con apuntar vagamente hacia un supuesto contraste entre los “modos de pensamiento” científico y jurídico. Es necesario considerar, en cambio, las consecuencias de los distintos objetivos que tanto la ciencia como el derecho persiguen, así como las limitaciones bajo las cuales dichos objetivos son perseguidos, y las diferentes culturas que involucran a ambas empresas. Desde esa perspectiva, es posible observar no sólo por (...) qué el derecho en algunas ocasiones pide más de lo que la ciencia puede dar en tanto que en otras recibe menos de lo que la ciencia podría dar, sino también por qué la simple dicotomía “inferencia científica” vs. “razonamiento jurídico” es en realidad más engañosa que útil. (shrink)

La metáfora no tiene ningún lugar en la ciencia, dicen algunos; al contrario, la metáfora es crucial para la ciencia, defienden otros. La ciencia es una empresa racional con una lógica distintiva propia; no, la ciencia no es en esencia diferente de la literatura, al igual que ésta, es una forma de creación de mundos. Hay un tipo de significado propiamente metafórico; no, las expresiones metafóricas poseen únicamente significados literales, en los cuales son simplemente falsas. Brillando por su ausencia, se (...) encuentra un razonable punto intermedio que Haack dibujará aquí. La metáfora es útil, pero no esencial, al trabajo científico; las metáforas no tienen una clase especial de significado, pero desempeñan un rol pragmático especial; el trabajo científico y la escritura de ficción tienen en común cosas importantes, pero hay también diferencias significativas entre estas dos empresas. Una vez que entendamos cómo funciona la ciencia (§1), y luego cómo funcionan las metáforas (§2), podremos articular las semejanzas, y diferencias, entre las metáforas científicas y las literarias. (§3). (shrink)

RESUMENSe analiza la integridad de la ciencia, entendida como la firme adhesión a valores epistemoló- gicos. Los valores fundamentales considerados son el respeto por las pruebas y el intercambio de pruebas. Paralelamente se examinan las amenazas actuales a estos valores, en particular en el campo de la investigación biomédica y farmacéutica.PALABRAS CLAVEINVESTIGACIÓN BIOMÉDICA, VALORES EPISTEMOLÓGICOS, INTERCAMBIO DE PRUEBAS, RESPETO POR LAS PRUEBASABSTRACTThe integrity of science understood as the firm adherence to epistemological values is analysed in this paper. Respect for evidence (...) and evidence-sharing are considered to be core values. At the same time, the author examines the current threats to these values, especially in the fields of biomedical and pharmaceutical research.KEYWORDSBIOMEDICAL RESEARCH, EPISTEMOLOGICAL VALUES, EVIDENCE-SHARING, RESPECT FOR EVIDENCE. (shrink)

Como se usa act ual ment e l a pal abr ainglesa “scientism”, es una verdad verbaltrivial que se debe evitar el cientismo –una actitud inapropiadamente deferentehaci a l a ci enci a. Pero const i t uye unacuestión sustancial determinar cuando,y por qué, la deferencia hacia las cienciases inapropiada o exagerada. Este artículot r a t a d e r e s p o n d e r a e s t a c u e s t i ó (...) narticulando “seis signos de cientismo”: eluso honorífico de “ciencia,” etc.; el empleode los símbolos de la ciencia de manerapuramente decorativa; la preocupaciónpor la demarcación; la preocupación porel “método científico”; la búsqueda derespuestas en las ciencias para preguntasque est án más al l á de su al cance; l anegación de la legitimidad o valor dela indagación no-científica o de actividades como escribirpoesía o producir arte.As t he Engl i s h wor d “ s c i e nt i s m” i sc ur r e nt l y us e d, i t i s a t r i vi al ve r baltruth that scientism-an inappropriatelydeferential attitude to science-should beavoided. But it is a substantial questionwhen, and why, deference to the sciencesis inappropriate or exaggerated. This papertries to answer that question by articulating“six signs of scientism”: the honorific useof “science,” etc.; using scientific trappingspur e l y de c o r a t i v e l y ; pr e o c c upa t i o nwith demarcation; preoccupation with“scientific method”; looking to the sciencesfor answers beyond their scope; denyingthe legitimacy or worth of non-scientific inquiry, or of writingpoetry or making art. (shrink)